对于HIV-1侵入的体-宿主相互作用
Sooin Jang1,2, Alan N Engelman1,2
1Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute , Boston, Massachusetts, USA.
Microbiology and molecular biology reviews : MMBR
|September 26, 2023
概括
艾滋病病毒-1囊体
科学领域:
- 病毒学 病毒学
- 结构生物学 结构生物学
- 分子生物学分子生物学
背景情况:
- 人类免疫缺陷病毒1型 (HIV-1) 囊蛋白围绕病毒遗传物质和必需酶形成一个保护性外.
- 了解HIV-1囊与宿主因子的相互作用对于病毒的进入和复制至关重要.
- 在感染过程中HIV-1囊脱涂的确切时间和位置仍然是争论的主题.
研究的目的:
- 审查HIV-1囊体和宿主因子在病毒进入和核进口过程中的复杂相互作用.
- 讨论有关HIV-1囊脱涂动态的当前研究问题.
- 为了突出向囊体与宿主相互作用的临床相关性.
主要方法:
- 对有关HIV-1囊体结构,功能和宿主相互作用的现有文献的综述.
- 分析最近关于体脱涂和核毛孔复合体穿越的发现.
- 讨论特定宿主因素的作用,如CPSF6,以及它们的结合动机 (例如,FG动机,PrLDs).
主要成果:
- 最近的证据表明,在核进口过程中,HIV-1囊体可能在很大程度上保持完好,并可能对NPC通道进行结构改造.
- 宿主因子,包括具有类域的宿主因子,与体外部结合,促进生产性感染.
- 核中逆转录的完成可能有助于体解体.
结论:
- 艾滋病毒-1囊体与宿主之间的相互作用对于病毒的侵入和随后的复制至关重要.
- 针对这些相互作用,如药物lenacapavir所示,提供了一个有前途的治疗策略.
- 需要进一步的研究,以充分阐明HIV-1囊脱涂的机制和时间.
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