Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Master Transcription Regulators02:23

Master Transcription Regulators

6.9K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.9K
Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

1.4K
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
1.4K
Drug-Receptor Interaction: Agonist01:25

Drug-Receptor Interaction: Agonist

2.5K
Agonists are drugs that interact with specific receptors in the body to produce a biological response. When an agonist binds to a receptor, it activates or enhances the receptor's function, leading to physiological effects. The interaction between agonist drugs and receptors is crucial for their therapeutic action in various medical treatments.
Agonists can bind to receptors in different ways. Some agonists bind directly to the receptor's active site, mimicking the endogenous...
2.5K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

7.4K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
7.4K
RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

9.2K
Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
9.2K
The Two-State Receptor Model01:29

The Two-State Receptor Model

2.0K
The two-state receptor model explains a drug's interaction with receptors, such as G protein-coupled receptors and ligand-gated ion channels, to induce or inhibit a biological response. When no natural ligands are present, a receptor exists in an equilibrium of inactive (Ri) and active (Ra) conformations. The inactive form does not produce a response, while the active form generates a basal effect known as constitutive activity.
The binding affinity of a drug determines its interaction with...
2.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

CCL19<sup>+</sup> fibroblasts define a proliferative niche in chronic lymphocytic leukemia.

bioRxiv : the preprint server for biology·2026
Same author

Elevated soil temperature alters nitrogen uptake, allocation and utilization in maize during the late vegetative stage.

Plant physiology and biochemistry : PPB·2026
Same author

Poge heart-saving decoction meliorates heart failure by suppressing apoptosis and fibrosis via regulation of the PI3K/AKT pathway.

Frontiers in pharmacology·2026
Same author

NFATC2::NUTM2 Fusion Defines a Novel Primary Pulmonary Epithelial Tumor With a Distinctive Immunophenotype.

The American journal of surgical pathology·2026
Same author

Activity-specificity balanced Au@Pt nanozyme immunoassay via Dual-Au deposition for enhanced mycotoxin detection.

Current research in food science·2026
Same author

Xbp1-driven lipid metabolism promotes immunosuppression in lung cancer: Jianpi Chutan Jiedu formula reshapes metabolic-immune crosstalk.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same journal

Secretory Circuits of Symbiosis in <i>Medicago truncatula</i>.

Molecular plant-microbe interactions : MPMI·2026
Same journal

A Splicing Twist in Ubiquitin-Mediated Immunity.

Molecular plant-microbe interactions : MPMI·2026
Same journal

Divergent Roles of CPK28 in Immune Homeostasis Across Land Plants.

Molecular plant-microbe interactions : MPMI·2026
Same journal

RasGEFs Play Essential Roles in the Biology of <i>Sclerotinia sclerotiorum</i> and <i>Botrytis cinerea</i> and Can Be Used as HIGS Targets for Disease Management.

Molecular plant-microbe interactions : MPMI·2026
Same journal

A Conserved Transcription Factor Domain Drives Necrotrophic Effector-Mediated Virulence and Putative Protein Interactions in <i>Parastagonospora nodorum</i>.

Molecular plant-microbe interactions : MPMI·2026
Same journal

Pathogen Species-Specific Differences in Induction of the Maize <i>Polyubiquitin</i> Gene Promoter in Transgenic Wheat.

Molecular plant-microbe interactions : MPMI·2026
查看所有相关文章

相关实验视频

Updated: Jul 15, 2025

An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness
06:21

An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness

Published on: May 7, 2018

6.5K

RxLR效应器:主调制器,修饰器和操纵器

Shumei Wang1, Hazel McLellan2, Petra C Boevink3

  • 1Department of Microbiology and Plant Pathology, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, CA, U.S.A.

Molecular plant-microbe interactions : MPMI
|September 26, 2023
PubMed
概括
此摘要是机器生成的。

菌种病原体利用Arg-任何氨基酸-Arg-Leu (RxLR) 效应器来操纵宿主免疫和过程. 了解RxLR效应体-宿主相互作用可以导致作物防护策略,防止诸如Phytophthora等病原体.

关键词:
在RxLR和EER图案中.有效率目标的目标.效应因子触发的易感性.这种类型的菌体.易感性因子易感性因子

更多相关视频

In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression
08:54

In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression

Published on: March 29, 2019

7.1K
Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

8.8K

相关实验视频

Last Updated: Jul 15, 2025

An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness
06:21

An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness

Published on: May 7, 2018

6.5K
In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression
08:54

In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression

Published on: March 29, 2019

7.1K
Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

8.8K

科学领域:

  • 植物病原体相互作用
  • 分子植物病理学 分子植物病理学
  • 虫生物学的生物学

背景情况:

  • 菌种病原体使用具有Arg-任何氨基酸-Arg-Leu (RxLR) 动图的细胞质效应器.
  • 这些RxLR效应器针对不同的宿主蛋白质,操纵细胞过程,如转录,后翻译修改和贩运.
  • 大约50%的向宿主蛋白质是植物免疫的负调节者.

研究的目的:

  • 审查目前对RxLR效应器演变,功能和识别的理解.
  • 探索RxLR效应器对宿主目标的不同作用模式.
  • 讨论利用RxLR效应体与宿主相互作用在作物保护方面的潜力.

主要方法:

  • 文献综述和对RxLR效应器现有研究的综合.
  • 分析效应器-目标相互作用及其对宿主过程的影响.
  • 检查植物免疫受体对RxLR效应物的识别.

主要成果:

  • RxLR效应器表现出多种作用模式,包括蛋白质稳定/不稳定,复杂变化,酶活性调节和重新定位.
  • 可通过核酸结合的氨酸丰富的重复蛋白 (NLR) 识别Avirulence RxLR效应体,为广泛的作物保护提供潜力.
  • 主体范围受到RxLR效应器与非主体植物中的目标相互作用或操纵目标的失败的影响.

结论:

  • 通过改变宿主目标,可以利用对RxLR效应物及其目标的了解来设计作物的耐药性.
  • 对保存的RxLR效应物的直接NLR识别为持久的作物免疫提供了一个有希望的途径.
  • 最近的发现表明RxLR效应体可能通过克拉中介的内细胞分裂进入宿主细胞.