变化的形态特征和结构共变连接性与ADHD儿童的口头工作记忆表现相关
Shengxiang Liang1,2,3, Li Huang4, Shiqi Zhan4
1National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
The British journal of radiology
|September 26, 2023
概括
儿童的注意力缺陷多动症 (ADHD) 与小脑灰质减少和大脑连接性改变有关,影响口头工作记忆 (VWM). 这些发现突出了小脑在ADHD中VWM缺陷中的作用.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 认知科学 认知科学
背景情况:
- 注意缺陷多动症 (ADHD) 与持续的口头工作记忆 (VWM) 缺陷有关.
- 之前的研究在VWM任务中发现了大脑区域的激活,但潜在的神经机制仍然不清楚.
- 研究结构性大脑变化为ADHD中VWM障碍提供了洞察力.
研究的目的:
- 检查ADHD儿童的结构共变网络连接和大脑形态.
- 为了将这些结构变化与VWM任务绩效相关联.
- 阐明ADHD中VWM缺陷的神经基础.
主要方法:
- 基于voxel的形态测量 (VBM) 用于评估灰质 (GM) 的体积.
- 结构共变网络分析探索了大脑连接模式.
- 26名ADHD儿童和26名健康对照 (HC) 进行了n-back VWM任务.
主要成果:
- 患有ADHD的儿童在小脑的右脑叶VI和左侧副海马回形中显示出较低的GM体积.
- 在右小脑叶VIGM体积和2-背VWM任务准确性 (VSD) 之间观察到正相关性.
- 在ADHD儿童中,右小脑叶VI和其他几个大脑区域之间发现结构连接性下降.
结论:
- 减少的GM体积和右小脑叶VI的结构连接性改变可能是ADHD中VWM缺陷的基础.
- 这些发现突出了小脑在ADHD中VWM表现中的关键作用.
- 这项研究促进了对ADHD神经基础的理解,并为VWM障碍的潜在干预提供了信息.
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