系统性炎症生物标志物作为胃食道腺癌患者的预后工具
Hannah C Puhr1,2, Clemens C Weirauch1, Flora Selimi1
1Division of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Journal of cancer research and clinical oncology
|September 26, 2023
概括
修改后的格拉斯哥预后得分 (mGPS) 有效预测胃食道腺癌患者的生存率. 较高的mGPS得分与较短的整体存活率相关,特别是在局部发达的疾病中.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 癌症预后 癌症预后
背景情况:
- 胃食道腺癌带有不良预后,即使在早期阶段.
- 系统性炎症是已知的癌症进展的驱动因素.
- 在欧洲胃食道癌症队列中,关于预后性炎症标志物的数据有限.
研究的目的:
- 评估胃食道腺癌中系统性炎症生物标志物的预后价值.
- 评估这些生物标志物与整体存活率 (OS) 之间的关联.
主要方法:
- 对中性粒细胞与淋巴细胞的比率 (NLR),白细胞与淋巴细胞的比率 (LLR),血小板与淋巴细胞的比率 (PLR),全身炎症反应指数 (SIRI) 和修改的格拉斯哥预后得分 (mGPS) 的分析.
- 从维也纳医学大学的769名胃食道腺癌患者收集的数据 (1990-2020年).
主要成果:
- 在所有患者群体中,较高的mGPS得分与较短的OS有显著的关联.
- 在多变量分析中,mGPS仍然是局部晚期疾病中OS的显著预测因素.
- 其他炎症标志物 (NLR,LLR,PLR,SIRI) 没有显著的预后价值.
结论:
- 修改后的格拉斯哥预后得分 (mGPS) 是一种可行的预后工具,用于局部晚期胃食道癌患者.
- mGPS可以帮助这些患者进行风险分层和治疗规划.
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