血液尿素的预后值对于感染性内心炎患者的短期死亡率
Qi Wang1, Jia Qiu1, Jie-Leng Huang1
1Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Infectious diseases and therapy
|September 26, 2023
概括
血尿素 (BUN) 是感染性内心炎 (IE) 患者死亡率的重要预测因素. 较高的BUN水平,特别是超过6.8mmol/L,独立地表明更高的住院和6个月死亡风险.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
背景情况:
- 血液尿素 (BUN) 是各种疾病中公认的预后因素.
- 在感染性内心炎 (IE) 中BUN的预测价值尚未先前评估.
研究的目的:
- 调查血液尿素 (BUN) 水平与被诊断患有感染性内心炎 (IE) 的患者的死亡率之间的关联.
- 确定BUN是否是IE患者短期死亡率的独立预测因素.
主要方法:
- 分析了1371名IE患者的队列,按入院BUN水平分类.
- 使用受限立方线和多变量分析来评估BUN与住院和6个月死亡率的关联.
- 进行了Kaplan-Meier和ROC曲线分析,以评估生存结果和最佳截止值.
主要成果:
- 住院死亡率为7.4%,六个月死亡率为9.8%.
- 在BUN水平和住院死亡率之间观察到线性关系.
- BUN水平>6.8 mmol/L独立地与增加住院 (aOR=2.365) 和6个月死亡率 (aHR=2.171) 相联系.
结论:
- 血尿素 (BUN) 是感染性内心炎 (IE) 患者短期死亡率的有价值的独立预测因子.
- 入院BUN水平,特别是超过6.8mmol/L,可以确定IE患者的不良结果风险较高.
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