低强度冲击波治疗与不同塔达拉菲尔疗法在患有PDE5抑制剂耐性勃起功能障碍的患者中的有效性:一项回顾性队列研究
Muhammed Arif İbis1, Fatih Ozkaya2, Zafer Tokatli3
1Department of Urology, Ankara University School of Medicine, Ankara, Turkey. maibis@ankara.edu.tr.
International urology and nephrology
|September 26, 2023
概括
将塔达拉菲尔与低强度冲击波疗法 (LI-SWT) 结合使用,可显著改善PDE5抑制剂耐药性患者的勃起功能障碍 (ED). 当与LI-SWT一起使用时,在每日或每天替换的塔达拉菲尔疗法之间没有发现显著的差异.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 安德罗学与人类学
- 再生医学是一种再生医学.
背景情况:
- 勃起功能障碍 (ED) 影响了男性人口的很大一部分.
- 固酶5型抑制剂 (PDE5i) 是ED的第一线治疗方法.
- 一部分ED患者对PDE5i仍然没有反应,需要采用替代治疗策略.
研究的目的:
- 为了比较单独使用低强度冲击波疗法 (LI-SWT) 与与PDE5i抵抗性ED患者的不同塔达拉菲尔疗法相结合的LI-SWT的疗效.
- 为了评估每天5毫克的塔达拉菲尔和每隔一天20毫克的塔达拉菲尔与LI-SWT一起使用.
主要方法:
- 一组105名患有PDE5i抗性ED的患者被分为三组:仅使用LI-SWT (A组),每天使用LI-SWT+5毫克塔达拉菲尔 (B组),每天使用LI-SWT+20毫克塔达拉菲尔 (C组).
- 国际勃起功能指数-5 (IIEF-5) 评分和勃起硬度评分 (EHS) 在基线,治疗后3个月和6个月被评估.
主要成果:
- 两种组合疗法 (B组和C组) 在IIEF-5和EHS分数显著改善,与LI-SWT单一治疗 (A组) 相比,在3个月和6个月后 (p < 0.001) 显著改善.
- 在所有组中,IIEF-5评分的改善在6个月内得到维持.
- 在每日使用塔达拉菲尔治疗方案 (B组) 和替代日治疗方案 (C组) 之间没有观察到统计学上显著的疗效差异.
结论:
- 与LI-SWT单独治疗相比,PDE5i与LI-SWT结合是一种优越的治疗策略,用于PDE5i耐药性ED患者.
- 在这种患者群体中,在每日或每天替换的塔达拉菲尔疗法之间做出选择似乎不会影响与LI-SWT一起使用的治疗结果.
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