在治疗自闭症谱系障碍中抑郁症的药物使用模式
Riley A Argonis1, Ernest V Pedapati1,2, Kelli C Dominick1,2
1Division of Child and Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue MLC 4002, Cincinnati, OH, 45229, USA.
Journal of autism and developmental disorders
|September 26, 2023
概括
在患有自闭症谱系障碍 (ASD) 的人群中,治疗抑郁症的药物显示出有限的有效性,由于缺乏有效性,近一半的药物被停止使用. 这凸显了针对ASD进行量身定制的抑郁症干预措施的需要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床药理学 临床药理学
背景情况:
- 抑郁症在患有自闭症谱系障碍 (ASD) 的人中很普遍,增加了严重后果的风险.
- 在ASD中治疗抑郁症的药物治疗是常见的,但对药物管理的系统数据很少.
研究的目的:
- 分析重大抑郁症 (MDD) 和ASD (2004-2012) 的历史处方模式.
- 以基于证据的见解为当前和未来的临床实践提供信息.
主要方法:
- 分析了大量的临床数据库,对ASD患者的处方实践进行分析.
- 鉴定了166名接受针对抑郁症的药物治疗的自闭症患者.
- 报告处方速率,治疗持续时间和停止治疗的原因.
主要成果:
- 塞特拉林,米尔塔扎平和素是最常被处方的抗抑郁药.
- 在241人开始服用药物的49%继续服用,平均持续时间为0.72年.
- 缺乏有效性是停止服用抑郁症药物的首要原因.
结论:
- 与神经类型人群相比,标准抑郁症治疗在患有自闭症的人群中可能效果较差.
- 有必要开发新的,针对ASD的抑郁症干预措施.
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