西尔德纳菲尔与安慰剂在高海拔地区的生理效应:系统性审查
Sangeeta Poudel1, Sandesh Gautam2, Purushottam Adhikari3
1Department of Emergency Medicine, Sparrow Hospital, Michigan State University, East Lansing, Michigan, USA.
High altitude medicine & biology
|September 26, 2023
概括
在休息和运动期间,西尔德纳菲尔有效降低高海拔地区的肺动脉压力. 这种药物在低氧条件下不会显著影响氧和,心率或血压.
科学领域:
- 生理学 生理学 生理学
- 药理学 药理学是指药理学的学科.
- 高度医学 高度医学
背景情况:
- 高空肺 (HAPE) 是一种危险的疾病,与肺高血压的增加有关.
- 西尔德纳菲尔是通过降低肺动脉压力 (PaP) 来治疗HAPE的潜在治疗方法.
研究的目的:
- 在高海拔地区系统地审查和比较西尔代纳菲尔与安慰剂的生理效应.
- 具体评估西德纳菲尔在低氧环境下对肺动脉压 (PaP) 的影响.
主要方法:
- 使用PubMed,EMBASE和Cochrane CENTRAL进行了一项系统性审查.
- 包括随机对照研究,评估在低氧条件下,在健康个体中西尔德纳菲尔的生理效应.
- 分析了模拟海拔2500至6400米之间的研究数据,包括正常和低压性缺氧.
主要成果:
- 在低氧条件下,在休息和运动期间,西尔德纳菲尔显著降低了肺动脉压力 (PaP).
- 在西尔代纳菲尔和安慰剂组之间,在动脉氧和度 (SpO2) 中没有发现显著差异.
- 心率,平均动脉压 (MAP) 和运动期间的心率不受西尔代纳菲尔的影响.
结论:
- 西尔德纳菲尔显示出显著的降低肺动脉压力 (PaP) 的能力,无论是在normobaric和hypobaric缺氧.
- 该研究发现,西尔代纳菲尔对关键的生理标志物如SPO2,心率,MAP或心率没有显著影响.
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