血清miR-1-3p的临床价值作为腹腔大动脉动脉瘤的潜在循环生物标志物
Jingjing Jing1, Miao Chang2, Shuyi Jiang3
1Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, Shenyang, China.
Annals of medicine
|September 26, 2023
概括
在患有腹腔大动脉瘤 (AAA) 的患者中,血清miR-1-3p水平显著降低. 较低的miR-1-3p与AAA风险增加有关,表明其作为诊断生物标志物的潜力.
科学领域:
- 心血管研究研究心血管研究
- 分子生物学分子生物学
- 生物标志物发现发现
背景情况:
- 腹腔大动脉瘤 (AAA) 具有危及生命的风险,但缺乏可靠的诊断生物标志物.
- 微RNAs (miRNAs) 正在成为AAA诊断和风险分层的潜在标记物.
研究的目的:
- 在腹腔大动脉动脉瘤 (AAA) 患者中评估miR-1-3p的血清水平.
- 在AAA中确定血清miR-1-3p的诊断值.
主要方法:
- 使用定量实时PCR测量200名AAA患者和200名对照者的血清miR-1-3p水平.
- 计算机断层扫描血管图 (CTA) 分析了AAA形态.
- 生物信息学工具确定了miR-1-3p目标基因及其功能.
主要成果:
- 与对照组相比,AAA患者的血清miR-1-3p水平明显较低.
- 较低的miR-1-3p水平与AAA风险增加相关 (OR=4.136) 并与动脉瘤大小相关.
- miR-1-3p具有0.672的AUC,84.5%的灵敏度和45.5%的特异性,证明了诊断能力.
结论:
- 血清miR-1-3p是一种有前途的循环生物标志物,用于腹腔大动脉动脉瘤 (AAA) 的发展.
- 通过各种生物过程,miR-1-3p可能在AAA病原发生过程中发挥关键作用.
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