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在评估基基基酸甲基纤维素酸盐无形固体分散物的性能时,媒体选择是否重要?

Pradnya Bapat1, Shubhajit Paul2, Naveen K Thakral2

  • 1Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.

Molecular pharmaceutics
|September 26, 2023
PubMed
概括

这项研究表明,在无形固体分散物 (ASD) 中,基甲基纤维素酸盐 (HPMCAS) 的溶解率受其溶解度和凝层 pH 的影响,而这种 pH 受缓冲容量和药物存在的影响.

关键词:
无形固体分散的无形固体分散缓冲区容量缓冲区容量缓冲区容量溶解机制 溶解机制 溶解机制溶解度取决于pH值的可溶性释放性能 释放性能 释放性能

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