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婴儿常见感染的周产期和其他危险因素:前性队列研究
Sanni Hyvönen1,2, Terhi Tapiainen3,4,5, Tytti Pokka3,6
1From the Department of Pediatrics, Tampere University Hospital, Tampere, Finland.
The Pediatric infectious disease journal
|September 26, 2023
概括
像分娩方式这样的围产因素不会增加常见的婴儿感染. 然而,剖腹产与生活的第一年尿路感染的风险更高有关.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 有限的前性数据存在于高收入国家的常见儿童感染的围产期风险因素.
- 这项研究研究了围产期因素影响婴儿在生命的第一年感染发作的假设.
研究的目的:
- 检查围产因素与婴儿常见感染的发病率和持续时间之间的关联.
- 确定可能增加生命第一年感染风险的特定围产期暴露.
主要方法:
- 一项前性出生队列研究 (健康和早期生命微生物群) 包括1052名在2016-2018年间出生的满期婴儿.
- 感染发作每周/每月在线跟踪,分析使用围产因素 (分娩方式,产后抗生素) 和环境暴露的多变量回归.
- 测量结果是生命第一年的传染性发作数量和持续时间.
主要成果:
- 婴儿在第一年平均经历了4.2次感染和44天的症状.
- 周产期因素,包括分娩方式和产后抗生素,与感染的总数或持续时间无关.
- 剖腹产与婴儿期尿路感染 (UTI) 的发生率增加有关 (aOR: 3.6,95% CI: 1.13-11.1).
- 男人性别和有兄弟姐妹与更高的感染发作数量有关.
结论:
- 周产期因素,分娩方式和产后抗生素似乎不是常见婴儿感染的重要危险因素.
- 剖腹产被认为是婴儿尿路感染的特定危险因素.
- 进一步的研究可能会探索与剖腹产相关的尿路感染风险背后的机制.
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