通过超敏感的3D结构可穿戴生物传感器对多种生物标志物的持续监测
Muqun Yang1, Han Wang2, Jing Cheng3
1Precision Medicine and Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen 518055, China; Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.
Cell reports methods
|September 26, 2023
概括
这项研究引入了一个可穿戴的生物传感器系统,用于持续监测健康生物标志物. 该设备可以实时,灵敏地检测葡萄糖和乳酸等代谢物,改善慢性疾病管理.
科学领域:
- 生物医学工程 生物医学工程
- 分析化学 分析化学
- 可穿戴技术可穿戴技术
背景情况:
- 慢性疾病需要经常监测生物标志物,但传统的诊断是耗时的和侵入性的.
- 现有的方法缺乏持续,实时的健康数据收集能力.
- 可穿戴设备为非侵入性,持续的健康评估提供了一个有希望的替代方案.
研究的目的:
- 开发一个完全集成的可穿戴系统,具有超敏感的3D结构生物传感器.
- 能够实时监测多种代谢物,以改善健康管理.
- 克服传统体外诊断的局限性,以持续监测.
主要方法:
- 一个超敏感的3D结构生物传感器的制造.
- 将生物传感器集成到一个完全可穿戴系统中.
- 在体内进行动物实验,以根据已确定的方法验证性能.
主要成果:
- 3D结构生物传感器显示了乳酸 (400-1400μM) 和葡萄糖 (0.1-8μM) 的广泛线性范围.
- 获得了高灵敏度:乳酸为460.5μA/mM·cm2,葡萄糖为283.09μA/mM·cm2.
- 可穿戴式生物传感器在动物研究中显示与已建立的诊断方法具有很高的一致性.
结论:
- 开发的可穿戴系统为实时生物标志物检测提供了一个敏感和可靠的平台.
- 这项技术有可能通过持续的健康监测彻底改变慢性疾病的管理.
- 该系统为多分析器可穿戴检测平台提供了一个有前途的方法.
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