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在乳腺癌幸存者中长期不良辐射疗法的种族和民族差异影响
Kevin Diao1, Xiudong Lei2, Weiguo He2
1Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
International journal of radiation oncology, biology, physics
|September 26, 2023
概括
在乳腺放射治疗后的长期生活质量 (QOL) 中存在种族和民族差异. 与白人患者相比,美国印第安人或阿拉斯加原住民,黑人和西班牙裔患者报告的乳腺和皮肤副作用更严重.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 乳腺癌的放射治疗可能会导致长期的乳腺和皮肤副作用,影响生活质量 (QOL).
- 众所周知,乳腺癌发病率存在种族和民族差异,但放射治疗后的长期QOL差异尚不清楚.
研究的目的:
- 调查乳腺放射治疗后长期质量生活结果的种族和种族差异.
- 确定与辐射不良影响相关的人口和治疗因素.
主要方法:
- 对631名患者 (诊断为2009-2014年) 进行了横截面调查研究,这些患者接受了隆瘤切除和放射治疗.
- BREAST-Q辐射不良影响得分测量了放射治疗对乳腺组织的影响.
- 多变量逻辑回归分析了特征和结果之间的关联.
主要成果:
- 与白人患者相比,美国印第安人或阿拉斯加土著 (AIAN),黑人和西班牙裔患者报告的QOL结果明显更差.
- 年龄较小 (<50岁),教育程度较低,胸罩杯尺寸较大 (D/E) 和目前的吸烟也与更糟糕的结果有关.
- 艾安,黑人和西班牙裔患者在皮肤颜色变化,角膜脱落,干燥,疼痛和刺激方面经历了更严重的变化.
结论:
- 在放射治疗后的长期乳房和皮肤质量生活中存在显著的种族和民族差异.
- AIAN,黑人和西班牙裔人口经历了更糟糕的结果,需要进一步的研究来理解和减轻这些差异.
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