作为癌细胞中氧依赖过程的调节器的S-氨基化和S-化
Elena V Kalinina1, Maria D Novichkova2
1RUDN University, Moscow, 117198, Russia. kalinina-ev@rudn.ru.
Biochemistry. Biokhimiia
|September 26, 2023
概括
反应性氧和物种 (ROS/RNS) 对癌细胞信号产生影响. 它们对蛋白质的可逆修饰控制细胞增殖和编程细胞死亡,影响瘤生长.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 氧化和化应激是癌症的标志,由活性氧和物种 (ROS / RNS) 驱动.
- ROS/RNS在瘤中表现出双重作用:高水平诱导细胞死亡,而低水平调节蛋白活性.
- 红氧依赖蛋白质的修饰,如S-氨基化和S-化,对于细胞信号传递至关重要.
研究的目的:
- 审查癌细胞中S-氨和S-化的机制.
- 探索这些修饰如何调节控制细胞增殖和细胞死亡的信号通路.
- 讨论氧化还原平衡,蛋白质修饰和瘤进展之间的关系.
主要方法:
- 文献综述侧重于癌症中氧化还原信号传递.
- 涉及ROS/RNS和蛋白质氨酸残留物的生物化学途径的分析.
- 检查控制蛋白质S-氨基化和S-化的监管系统.
主要成果:
- S-氨基化和S-化是通过ROS/RNS对囊残留的可逆修饰.
- 这些修改起到氧化还原开关的作用,改变信号蛋白活性.
- 蛋白质谷氨基化/脱和化/脱的平衡决定了细胞的氧化还原状态和信号结果.
- 这些变化的程度和比例会影响癌细胞的增殖和细胞死亡.
结论:
- S-氨基化和S-化是癌症中关键的氧化还原依赖性调节机制.
- 这些可逆的蛋白质修饰在控制癌细胞信号传递,增殖和生存方面发挥着至关重要的作用.
- 了解这些途径对于破译瘤生长动态和开发向疗法至关重要.
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