在性别肯定激素治疗期间,下丘脑体积和相关子单元的变化
Melisande E Konadu1, Murray B Reed1, Ulrike Kaufmann1
1From the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Kranz, Lanzenberger, Spies); the Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria (Konadu, Reed, Handschuh, Spurny-Dworak, Klöbl, Schmidt, Godbersen, Briem, Seiger, Baldinger-Melich, Lanzenberger, Spies); the Department of Obstetrics and Gynecology, Medical University of Vienna, Austria (Kaufmann); the Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong (Kranz).
性别确认激素治疗 (GHT) 对跨性别女性 (TW) 的下丘脑体积产生影响,观察到特定的下丘脑子单元的减少. 这些变化突出显示了大脑的变化.
科学领域:
- 神经内分泌学神经内分泌学
- 神经成像是一种神经成像.
- 内分泌学 在内分泌学.
背景情况:
- 性别确认激素疗法 (GHT) 具有类效应,包括改变区域大脑体积.
- 下丘脑对神经内分泌,情绪和认知功能至关重要,是研究GHT效应的关键目标.
- 由于该区域的解剖学和功能异质性,研究下丘脑子单元体积至关重要.
研究的目的:
- 为了评估性别肯定激素治疗 (GHT) 后的全和亚单位下丘脑体积的变化.
- 为了探索GHT对跨性别个体大脑结构的影响,与 cisgender 对照相比.
- 了解GHT对下丘脑的子单位特异性影响.
主要方法:
- 106名参与者 (38名跨性别男性[TM],15名跨性别女性[TW],32名跨性别女性[CW],21名跨性别男性[CM]) 接受了两次MRI扫描.
- 在扫描之间 (中位数间隔145天),TW和TM接受了GHT (雌激素/抗雄激素或).
- 使用FreeSurfer对下丘脑体积进行了细分;反复测量ANCOVA测试了GHT效应.
主要成果:
- 对于总和亚单位的下丘脑体积,发现了显著的组 × 时间相互作用效应.
- 跨性别女性 (TW) 在GHT (p_corr <0.01) 后,在几个下丘脑子单元中显示出体积的减少.
- 在特定子单位 (p_corr < 0.05) 中,TW 变化与 cisgender 男人 (CM) 和 cisgender 女人 (CW) 有显著差异.
结论:
- 性别确认激素疗法 (GHT) 对跨性别女性 (TW) 下丘脑体积产生子单位特异性影响.
- 这些发现与雌激素和雄激素对大脑体积的已知影响一致.
- 需要进一步的研究来探索与GHT相关的心理和行为变化.
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