验证经济评估的适应性方法的严谨性
Akashdeep Singh Chauhan1, Deepshikha Sharma1, Abha Mehndiratta2
1Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
BMJ global health
|September 26, 2023
概括
经济评估的适应性卫生技术评估 (aHTA) 方法在转移到新环境时显示出显著的成本变化. 需要进一步的研究来提高这些成本调整方法的准确性,以便更好地做出决策.
科学领域:
- 卫生经济学 卫生经济学
- 卫生技术评估 卫生技术评估
- 药物经济学 药物经济学
背景情况:
- 关于将经济评估 (EE) 和医疗技术评估 (HTA) 调查结果在不同国家推广,存在争议.
- 适应性HTA (aHTA) 方法,如模型适应和价格基准分析,用于证据转移.
- 本研究评估了在不同国家背景下对EE的HTA方法的准确性.
研究的目的:
- 通过使用选定的aHTA方法,评估适应经济评估结果的准确性.
- 将调整后的成本和成本效益结果与印度当地参考研究进行比较.
主要方法:
- 采用了精选的aHTA方法,将全球EE发现适应印度环境.
- 确定了两个干预措施的印度EE研究和全球EE研究.
- 在调整结果之前进行质量和可转移性检查.
- 将调整后的结果与印度参考研究进行了比较.
主要成果:
- 与印度参考研究相比,调整后的成本估计有很大差异.
- 对于trastuzumab,调整后的成本是6-11倍高;对于强度调节的放射治疗,调整后的成本是12-35%低.
- 适应的增量成本效益比率 (ICER) 是trastuzumab的3.5-8倍,强度调节放射治疗的1.5-2.5倍.
结论:
- 由于成本差异很大,aHTA方法的发现需要谨慎解释.
- 开发更强大的HTA成本调整方法是必要的.
- aHTA可以通过早期识别潜在的成本效益低下的干预措施,帮助在HTA中优先考虑主题.
相关概念视频
01:15Data Validation
182
Method validation is a crucial process in analytical chemistry designed to confirm that a given method consistently produces reliable and high-quality results. This process is essential when a method is applied to different sample matrices or when procedural modifications are made, ensuring that the results meet acceptable standards across various applications.
Key parameters for method validation include:
Key parameters for method validation include:
182
01:29Econometric Views (EViews)
162
Econometric Views, often stylized as EViews, is a package that merges statistical analysis with econometric studies. It is designed to provide tools for time series analysis, forecasting, and econometric model simulation. The software originated from MicroTSP software and has evolved significantly since its inception in 1981. The history of EViews is marked by a continuous effort to enhance its computational speed and user interface. It was initially developed for large computing systems but...
162
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
145
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
145
01:09Decision Making: P-value Method
5.5K
The process of hypothesis testing based on the P-value method includes calculating the P- value using the sample data and interpreting it.
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim is also stated. These statements can act as null and alternative hypotheses: a null hypothesis would be a neutral statement while the alternative hypothesis can...
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim is also stated. These statements can act as null and alternative hypotheses: a null hypothesis would be a neutral statement while the alternative hypothesis can...
5.5K
01:29Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
72
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
72
01:20Comparing the Survival Analysis of Two or More Groups
218
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
218