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Updated: Jul 15, 2025

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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耐火性 pembrolizumab 免疫治疗相关的结肠炎需要在不活跃的 HBcAb 载体中进行生物治疗

Nidaa Rasheed1, Rajan Anand2, Mark Maddox3

  • 1Internal Medicine, University of California San Francisco, Fresno, California, USA nidaa.rasheed@ucsf.edu.

BMJ case reports
|September 26, 2023
PubMed
概括

免疫检查点抑制剂,如 pembrolizumab,可以引起严重的免疫媒介腹. 这一案例凸显了管理这种副作用的重要性,特别是在患有慢性乙型肝炎等潜在疾病的患者中.

关键词:
胃肠道出血发生胃肠道系统 胃肠道系统乙型肝炎 B 型肝炎恶性疾病和免疫抑制

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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