纳尔特雷克松/布普治疗过度饮食障碍:一个随机,双盲,安慰剂对照的试验
Carlos M Grilo1, Janet A Lydecker1, Ania M Jastreboff2
1Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Obesity (Silver Spring, Md.)
|September 26, 2023
概括
纳尔特雷克松/布普罗在患有暴饮暴食障碍 (BED) 的患者中没有有效地减少暴饮暴食. 然而,该药物确实促进了该人群的显著减肥.
科学领域:
- 精神病学和行为科学 精神病学和行为科学
- 药理学和治疗学 药理学和治疗学
- 肥胖问题研究研究
背景情况:
- 暴饮暴食障碍 (BED) 是一种常见的精神疾病,经常与肥胖同时发生.
- 有限的基于证据的治疗方法,特别是药物治疗方法,可用于BED.
- 这项研究调查了BED.的潜在药理干预.
研究的目的:
- 评估纳尔特雷/布普罗在治疗过度饮食障碍 (BED) 的疗效.
- 为了评估药物的有效性,在肥胖和非肥胖的个人与BED.
- 为了确定纳尔特雷/布罗对暴饮暴食频率,缓解率和体重变化的影响.
主要方法:
- 一个为期12周的随机,双盲,安慰剂对照试验.
- 八十九名患有BED的患者随机分配给接受纳尔特雷/布普罗或安慰剂.
- 按肥胖状况和性别分层,对92.1%的参与者进行治疗后评估.
主要成果:
- 与安慰剂相比,纳尔特雷/布罗并没有显著降低暴饮暴食的频率或改善缓解率.
- 肥胖状况没有影响过度饮食的结果.
- 与安慰剂相比,纳尔特雷克松/布普罗的体重减轻比例显著增加,体重减轻率达到≥5%的比例也更高.
结论:
- 纳尔特雷克松/布普罗在患有BED的患者减肥方面表现出有效性.
- 与安慰剂相比,这种药物在减少暴饮暴食方面没有表现出有效性.
- 肥胖状况没有影响药物的有效性对暴饮暴食或体重结果.
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