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从新生儿中Staphylococcus capitis隔离的临床结果,英格兰,2015-2021年:回顾性病例控制研究
Jin-Min Yuan1, Christopher Nugent2, Allegra Wilson3
1Field Service, UK Health Security Agency, London, UK JinMin.Yuan@ukhsa.gov.uk.
Archives of disease in childhood. Fetal and neonatal edition
|September 26, 2023
概括
与其他凝结酶阴性葡萄球菌 (CoNS) 种类相比,婴儿感染的葡萄球菌对离院生存率或30天死亡率没有显著影响. 这一发现对于了解新生儿单位爆发和患者结果至关重要.
科学领域:
- 新生儿医学 新生儿医学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 凝聚酶阴性葡萄球菌 (CoNS) 越来越多地在无菌地点被发现,全球新生儿单位报告了葡萄球菌头炎疫情.
- 与其他CONS物种相比,了解S.capitis的特定影响对于临床管理至关重要.
研究的目的:
- 为了比较患有S. capitis无菌部位感染的婴儿在出院后的存活率和30天死亡率,与其他CONS物种相比.
- 分析基于英国住院婴儿大量数据集的结果.
主要方法:
- 对住院婴儿 (长达90天) 进行了回顾性病例控制研究,从无菌地点检测到CoNS.
- 数据链接包括实验室报告,死亡率数据和新生儿单位的入院.
- 多变量逻辑回归分析出院生存率和30天死亡率,并进行了灵敏度分析.
主要成果:
- 在近14000名婴儿中发现了超过16000次CoNS发作,极度早产和低出生体重婴儿的发病率最高.
- 在初级分析中,在S.capitis和其他CoNS物种之间没有观察到生存到出院或30天死亡率的显著差异.
- 敏感性分析证实,对于常见的CONS物种 (S. epidermidis,S. capitis,S. haemolyticus,S. warneri) 没有结果差异,但其他CONS物种的总和显示出更高的不良事件风险.
结论:
- 与其他常见的CONS物种相比,患有S. capitis无菌部位感染的婴儿在生存或30天死亡率上没有显著差异.
- 这些发现表明,S. capitis可能与该群体中的其他CONS相比没有明显的死亡风险.
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