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喉软骨瘤的治疗策略:对43例病例的多中心研究
Marianne Schleich1, Laurent Laccourreye2, Remi Marianowski3
1Department of Otolaryngology-Head and Neck Surgery, University Hospital of Tours, 2 Boulevard Tonnellé, 37000, Tours, France. marianne.schleich@hotmail.fr.
概括
喉软骨瘤治疗的比较表明,喉保存方法在大多数患者中保持功能,而不会影响生存. 这些保守的方法被推用于初始治疗.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 手术瘤学手术瘤学
- 罕见的癌症 罕见的癌症
背景情况:
- 喉软骨瘤是一种罕见的恶性瘤,主要影响状软骨.
- 最佳的治疗策略缺乏确定的指导方针,需要进行比较结果分析.
研究的目的:
- 为了比较喉软骨瘤的治疗结果.
- 为了评估全喉切除术与保守的喉保存方法的疗效.
主要方法:
- 追溯分析了9个法国第三级护理中心43名患者的情况.
- 整体喉切除术和保守治疗 (内镜除,甲状腺切除术,部分喉切除术) 之间的结果比较.
- 卡普兰-梅尔总体生存率和喉保存的生存分析.
主要成果:
- 在保守治疗下,喉功能在96% (1年) 和75% (5年) 的患者中得到了保留.
- 保守治疗没有对整体生存率产生负面影响.
- 31名患者最初接受了喉保护治疗,而12名患者接受了全喉切除术.
结论:
- 喉保护策略对于治疗喉软骨瘤是有效的.
- 建议首先考虑保守治疗,以保持喉功能.
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