在人类的间隔运动中模拟长期促进呼吸
Stanley M Yamashiro1,2, Takahide Kato3, Takaaki Matsumoto4
1Biomedical Engineering Department, University of Southern California, Los Angeles, CA, 90089-1111, USA. syamash@usc.edu.
Annals of biomedical engineering
|September 26, 2023
概括
通过运动和二氧化碳 (CO2) 吸入,可以诱导呼吸的长期促进 (LTF),超过间歇性缺氧的影响. 数学模型显示,这种反应涉及神经元激发和抑制之间的平衡.
科学领域:
- 生理学 生理学 生理学
- 呼吸系统控制 呼吸系统控制
- 运动科学 运动科学
背景情况:
- 呼吸的长期促进 (LTF) 通常由间歇性缺氧和随后的化学受体刺激开始.
- 通过联合运动和二氧化碳 (CO2) 吸入,可以实现可比的化学受体刺激,这可能导致LTF.
研究的目的:
- 通过联合运动和二氧化碳吸入来研究诱导LTF的可能性.
- 用数学模型分析动态反应,以区分神经和化学受体介导的CO2对LTF的影响.
主要方法:
- 七名健康受试者进行了3%吸入二氧化碳的间歇运动.
- 在轻度运动 (40W) 时估计了周围化学受体的敏感性,使用空气或3%的CO2.
- 数学模型被应用到动态的呼吸反应,在45%的最大氧气吸收运动期间和之后.
主要成果:
- 周围化疗受体的敏感性在轻度炼期间与3%的CO2相比,休息水平大约翻了一番.
- 在高强度运动后恢复期间,通风量显著增加 (17.0 ± 2.48 L/min,p < 0.001),与LTF一致.
- 模型拟合表明,LTF增强遵循了二阶动态,表明神经元可塑性.
结论:
- 运动和二氧化碳吸入的组合可以诱导呼吸的显著LTF.
- 观察到的LTF超过了仅通过间歇性缺氧实现的LTF.
- 底层机制涉及自我激发和自我抑制的神经元池之间的平衡,表明神经可塑性.
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