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Disorders of the Male Reproductive System01:20

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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
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Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
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Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
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甲状腺疾病和男性性功能障碍

Rohan Morenas1, Danish Singh1, Wayne J G Hellstrom2

  • 1Department of Urology, Section of Andrology, Tulane University School of Medicine, New Orleans, LA, USA.

International journal of impotence research
|September 26, 2023
PubMed
概括

甲状腺疾病显著影响男性性功能障碍 (SD),影响勃起功能,精子发生和下丘脑-垂体-阴茎轴. 认识到这种联系对于诊断和管理男性性健康至关重要.

科学领域:

  • 内分泌学 在内分泌学.
  • 泌尿器科 泌尿器科 泌尿器科 泌尿器科
  • 生殖医学 生殖医学

背景情况:

  • 早期的研究忽略了甲状腺激素参与男性生殖功能.
  • 近几十年来,越来越多的证据表明甲状腺疾病与男性性功能障碍 (SD) 有关.

研究的目的:

  • 从1963年到2022年,审查有关甲状腺疾病和男性SD的文献.
  • 定义诊断考虑因素,病理生理学和二次性甲状腺失调导致的SD的管理策略.

主要方法:

  • 进行了临床和临床前研究的综合文献审查.
  • 专注于1963年至2022年间发表的研究.

主要成果:

  • 甲状腺失调与勃起功能障碍,射精功能障碍和精子生成障碍有关.
  • 脑下垂体 - 脑下垂体 - 淋巴腺轴的破坏是一个关键的病理生理机制.
  • 甲状腺疾病是男性SD的重要因素.

结论:

  • 甲状腺疾病是男性性功能障碍病理生理学的组成部分.
  • 本综述为临床医生评估同时患有甲状腺和SD问题的患者提供了一个框架.

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  • 需要进一步的研究,以充分阐明底层机制.