患有重叠性易怒肠综合征和功能性消化不良症患者的肠道屏障和肠道微生物群
Aleksandra Kovaleva1, Elena Poluektova1, Roman Maslennikov2
1Sechenov University, Moscow, Russia, 119435.
肠道屏障功能障碍和肠道失调与功能性肠道疾病有关. 这项研究发现,在患有重叠性易怒肠综合征和功能性消化不良症的患者中,障碍障碍与症状严重程度和肠道微生物群变化相关.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 肠道生理学 肠道生理学
背景情况:
- 功能性肠道疾病与肠道屏障障障碍和肠道失生症有关.
- 了解这些干扰对于管理诸如刺激性肠综合征和功能性消化不良等疾病至关重要.
研究的目的:
- 调查不同层次肠道屏障障碍的生物标志物与患有重叠腹占主导地位的刺激性肠综合征和功能性消化不良症 (IDFO) 患者的症状严重程度之间的相关性.
- 探索这些生物标志物与肠道微生物群组成之间的关系.
主要方法:
- 该研究包括45名IDFO患者和16名健康对照.
- 通过内镜活检,分析了不同肠层内的内皮淋巴细胞,粘膜性叶绿素,脂肪酸结合蛋白 (FABP) 和粘素-2 (MUC-2) 的存在.
- 用16S rRNA基因测序来评估肠道微生物组成.
主要成果:
- 在所有研究的层中,IDFO患者的肠道屏障障障碍生物标志物增加.
- 特定的生物标志物与症状严重程度有显著的相关性,包括膨胀,紧张,腹,腹部膨胀,胃灼热和上胃灼热.
- 所有肠道屏障透性生物标志物都与某些肠道微生物群的丰富性有关.
结论:
- 患有IDFO的患者表现出所有层的肠道屏障功能受损.
- 这种干扰与临床症状的严重程度有显著的关联.
- 肠道微生物群的变化也与观察到的肠道屏障功能障碍有关.
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