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单细胞衍生的树突细胞的功能和自受B型肝炎病毒感染的影响

Hua Xu^1,2, Juan Kang¹, Shan Zhong¹

¹Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, the Second Affiliated Hospital, Chongqing Medical University, No.288 Tianwen Rd., Nan Ping District, Chongqing, 400060, People's Republic of China.

|September 26, 2023

概括

乙型肝炎病毒 (HBV) 感染增加了患者的树突细胞激活和自. 这种增强的免疫细胞功能可能与慢性HBV感染期间树突细胞自性增加有关.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
细胞生物学细胞生物学

背景情况:

树突细胞 (DCs) 和它们在乙型肝炎病毒 (HBV) 感染免疫力中的自的作用仍在争论中.
这项研究调查了在HBV感染中DC表型,功能和自.

研究的目的:

为了澄清树突细胞及其自在HBV感染免疫反应中的有争议的作用.
分析慢性HBV感染患者树突细胞的表型,功能和自途径.

主要方法:

来自健康捐赠者和慢性HBV患者的单细胞衍生的树突细胞被刺激.
通过流细胞计进行表型分析,通过ELISA进行细胞因子分泌,通过西部斑点和免疫光检测进行自蛋白.

主要成果:

来自HBV患者的树突细胞表现出MHC-II,CD80和CD86的更高表达,当它们被HepG2.2.15超自然剂刺激时.
在HBV患者的DC中观察到TNF-α,IL-10和IL-12的分泌量增加.
自相关蛋白质 (ATG5,LC3) 在HBV患者在HBV再暴露后的DC中显著上调.

结论:

慢性HBV感染中的树突细胞表现出增强的抗原呈现和共刺激分子表达.
在HBV感染中,树突细胞激活的增加可能与自的增加有关.

关键词:

自自是一种自的过程.细胞因子细胞因子乙型肝炎病毒的感染.单细胞衍生的树突细胞细胞.现象型现象型是一种表现型.

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