阻塞性睡眠呼吸暂停:COVID-19脑病变的主要危险因素?
Gautier Breville1,2, François Herrmann3, Dan Adler4
1Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA. gautier.breville@pennmedicine.upenn.edu.
BMC neurology
|September 26, 2023
概括
阻塞性睡眠呼吸暂停 (OSA) 的高风险与更严重的COVID-19急性脑病变 (AE) 有关. 这表明OSA可能会使个人易患严重的COVID-19AE和持久的健康问题.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 睡眠医学 睡眠医学
背景情况:
- 冠状病毒疾病2019 (COVID-19) 可能导致急性脑病变 (AE).
- 阻塞性睡眠呼吸暂停 (OSA) 是一种常见的睡眠障碍.
- 目前尚不清楚OSA风险与COVID-19AE严重程度之间的关系.
研究的目的:
- 评估阻塞性睡眠呼吸暂停 (OSA) 高风险对COVID-19急性脑病变 (AE) 严重程度的影响.
主要方法:
- 在2020年3月至2021年11月期间,97名COVID-19AE患者被评估.
- 根据OSA高风险 (修改后的NOSAS得分≥8) 和低风险 (mNOSAS<8) 进行分组.
- 对比了临床,生物,神经成像 (MRI),EEG和CT发现. 使用RASS和CAM分数来评估AE的严重程度.
主要成果:
- 超过80%的COVID-19AE患者有OSA (mNOSAS ≥8) 的高风险.
- 高OSA风险患者表现出更严重的COVID-19AE (84.8%vs27.8%),更长的AE持续时间 (27.9vs16.9天),以及在出院时更高的残疾 (mRS≥3在58.2%vs16.7%).
- 高OSA风险与严重COVID-19AE风险增加14.5倍和脑血管增强的更高患病率 (98.1%对20.0%) 相关.
结论:
- 在OSA的高风险和COVID-19 AE.的严重程度增加之间存在显著的关联.
- 高风险的OSA可能是严重的COVID-19AE的诱导因素.
- 这种关联表明,在患有这两种疾病的患者中,可能会出现长期的后果.
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