癌性心脏病的患病率,一年发生率和预测因素
Isabel Mattig1,2,3,4, Maximilian Richard Franke1,4,5, Rene Pschowski6
1Deutsches Herzzentrum der Charité, Department of Cardiology, Angiology and Intensive Care Medicine, Campus Charité Mitte, Berlin, Germany.
Cardiovascular ultrasound
|September 26, 2023
概括
癌性心脏病 (CHD) 影响6-7%的神经内分泌瘤 (NET) 患者. 较高的5-氨酸 (5-HIAA) 水平预测心脏病的发展,突出其在NET患者的早期检测的重要性.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 生物化学 生物化学
背景情况:
- 神经内分泌瘤 (NET) 患者的癌症性心脏病 (CHD) 导致了来自膜功能障碍和心力衰竭的显著发病率和死亡率.
- 在NET患者中评估心脏病发病率和发病率对于了解疾病影响至关重要.
研究的目的:
- 确定NET患者中心血管疾病的患病率和一年发生率.
- 确定心血管疾病发展的预测因素,包括瘤特征,实验室标记物和心声回声学发现.
主要方法:
- 一项前性单中心试验,涉及47名没有先前诊断为心脏病的NET患者.
- 综合诊断包括基线和一年后的心声回声学.
主要成果:
- 基线上心脏病的患病率为6%,一年发生率为6.8%.
- 尿中5-氨酸 (5-HIAA) 的升高是CHD发展的唯一预测因子 (OR,1.004;95% CI,1.001-1.006).
- 染色素A (CgA) 和Ki 67%缺乏对CHD的预测价值.
结论:
- 在NET患者中,心血管疾病的患病率和一年发生率约为6-7%.
- 尿路5-HIAA是该人群中癌性心脏病发展的重要预测标志物.
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