患者决策辅助在主流化卵巢癌妇女的基因检测:一个前性队列研究
Monika Sobocan1, Dhivya Chandrasekaran2, Michail Sideris1,3
1Wolfson Institute of Population Health, Barts CRUK Cancer Centre, Queen Mary University of London, London, UK.
BJOG : an international journal of obstetrics and gynaecology
|September 27, 2023
概括
患有卵巢癌的患者更喜欢更长的决策辅助器 (DAs) 进行基因测试,报告更高的满意度和理解,而不会增加痛苦. 然而,那些正在接受治疗或复发的人更喜欢更短的DA.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 患者的决策制定 患者的决策
背景情况:
- 遗传检测对于卵巢癌 (OC) 管理至关重要.
- 患者对决策辅助工具 (DA) 的理解和满意度可以影响吸收和坚持.
- 对OC患者进行遗传检测的DA的最佳格式尚未确立.
研究的目的:
- 为了比较患者对简短 (核心) 和详细/广泛的DA的偏好,在OC诊断时进行基因检测.
- 为了评估与不同DA格式相关的满意度,理解和情感幸福感.
主要方法:
- 在SIGNPOST研究中的一项队列研究招募了患有高度非性表皮OC的女性.
- 患者评估了短期和长期DA,使用国际患者决策辅助标准 (IPDAS) 原则开发.
- 评估了满意度,可读性,理解力,情感福祉和DA偏好.
主要成果:
- 与较短的DA相比,较长的DA导致更高的满意度 (86%与58%) 和更好的理解 (p<0.001).
- 在DA格式之间没有观察到情绪结果的显著差异.
- 总的来说,74%的患者更喜欢长时间的DA,但那些接受治疗的人,复发,或年长的妇女更喜欢短时间的DA.
结论:
- 详细的DA增强了经过基因测试的OC患者的满意度和理解,而不会增加情绪困扰.
- 患者对DA长度的偏好因治疗状态,疾病复发和年龄而异.
- 根据个别患者情况定制DA格式,可以优化OC遗传检测中的共享决策.
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