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过敏性气道炎症源于肠道炎症和泄漏,在喘小鼠模型中出现

Balachandar Selvakumar¹, Mariam Wed Eladham¹, Shirin Hafezi¹

¹Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, 27272, UAE.

Advanced biology

|September 27, 2023

概括

这项研究揭示了肠道是过敏呼吸道炎症 (AAI) 在小鼠喘模型的起源. 肠道炎症和泄漏在肺炎之前和驱动肺炎,这表明肠道发起了喘的发展.

科学领域:

免疫学免疫学免疫学
胃肠病学胃肠病学
肺部病理学肺部病理学

背景情况:

喘是一种由2型免疫反应驱动的过敏呼吸道炎症性疾病.
越来越多地认识到过敏呼吸道疾病和肠道疾病之间的关联.
过敏性气道炎症 (AAI) 的主要起源和初始机制尚不清楚.

研究的目的:

调查AAI发展中的最初贡献器官和机制.
确定肠道是否在启动AAI中发挥主要作用.
在小鼠喘模型中阐明肠道炎症和肺炎之间的关系.

主要方法:

使用了一种小鼠喘模型,没有初始局部过敏原对肺部的挑战.
评估了肠道炎症,2型免疫介导体 (IL-4,IL-13,STAT6),乙素和Th2细胞.
测量了肠道泄漏标记物,紧结蛋白表达,肺屏障透性和脂多糖结合蛋白 (LBP).

主要成果:

显著增加的肠道炎症,肠道泄漏和2型媒介被观察到没有肺部过敏原挑战.
肠道和肺组织中紧结蛋白的表达减少表明屏障功能障碍.
在肺组织中,肺屏障的透性增加和IL-4,IL-13,LBP和埃索诺菲尔水平升高.
当地肺部过敏原的挑战进一步加剧了这两个器官的炎症机制.

结论:

肠道被确定为过敏呼吸道炎症 (AAI) 的主要来源地.
来自肠道的炎症反应转移到肺部,协调AAI的发展.
这表明在喘的发病过程中存在肠肺轴,肠道启动炎症级联.

关键词:

航空公司航空公司航空公司过敏是一种过敏.障碍物功能障碍障碍物功能障碍在这里,我们可以看到子子.肠道泄漏肠道泄漏炎症炎症炎症鼠标模型鼠标模型

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