日本绝经妇女的雌激素和孕激素处方的现实实践:使用日本索赔数据库的描述性研究
Yoshihide Inayama1,2, Kayoko Mizuno2, Miho Egawa1
1Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
The journal of obstetrics and gynaecology research
|September 27, 2023
概括
日本更年期妇女的雌激素处方正在增加,特别是在年轻年龄组. 许多有子宫的女性没有接受推的雌激素-孕激素治疗 (EPT).
科学领域:
- 生殖医学 生殖医学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 更年期激素治疗 (MHT) 是治疗更年期症状的常见方法.
- 雌激素疗法 (ET) 和雌激素-孕激素疗法 (EPT) 适用于绝经妇女.
- 对MHT的临床实践模式在全球范围内有所不同,需要实践调查.
研究的目的:
- 调查日本更年期妇女的雌激素和孕激素处方的现实世界临床实践.
- 分析雌激素和孕激素启动和同时使用的趋势.
- 根据患者的特征和子宫切除状态,识别MHT处方中的模式.
主要方法:
- 使用日本医疗保健数据库进行了横截面研究.
- 分析包括雌激素处方和同时使用的孕激素处方.
- 数据涵盖2005年1月至2021年12月的时间.
主要成果:
- 2009年以后,在50-59岁的女性中,雌激素处方增加了.
- 透皮雌激醇成为60岁以下没有切除子宫的女性的主要雌激素形式.
- 大约30%的女性在子宫内被处方雌激素≥180天没有同时接受孕激素.
- 孕激素的使用减少了medroxyprogesterone酸盐,但增加了dydrogesterone和通过皮肤给予的norethisterone acetate.
结论:
- 在日本,大量有子宫的妇女接受雌激素治疗 (ET) 而不是雌激素-孕激素治疗 (EPT).
- 这种处方模式与推EPT为子宫女性的指导方针有所不同.
- 现实世界的数据突出显示了遵守MHT指南的潜在差距.
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