描述精神分裂症和心血管疾病风险因素的共同遗传基础
Linn Rødevand1, Zillur Rahman1, Guy F L Hindley1
1Norwegian Center for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo (Rødevand, Rahman, Hindley, Smeland, Frei, Tekin, Kutrolli, Bahrami, Hoseth, Shadrin, Lin, Steen, Andreassen); Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Hindley); Center for Bioinformatics, Department of Informatics, University of Oslo, Oslo (Frei); Division of Mental Health, Helse Møre Romsdal HF, Kristiansund, Norway (Hoseth); Department of Medical Genetics, Oslo University Hospital, Oslo, and NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway (Djurovic); Multimodal Imaging Laboratory and Departments of Radiology, Psychiatry, and Neurosciences, University of California San Diego, La Jolla (Dale).
精神分裂症和心血管疾病 (CVD) 之间的遗传重叠存在像吸烟和BMI这样的风险因素. 这表明精神分裂症患者对心血管疾病的遗传责任各异,影响并发症风险.
科学领域:
- 精神病学是一个精神病学.
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
背景情况:
- 精神分裂症 (SCZ) 与较高的心血管疾病 (CVD) 风险有关,个人风险有所不同.
- 在SCZ和CVD之间共享的遗传基础尚未完全理解.
- 调查这种遗传重叠可以澄清SCZ中的心血管疾病风险.
研究的目的:
- 调查精神分裂症和心血管疾病风险因素之间的遗传重叠.
- 识别特定的共同遗传位置及其特征.
主要方法:
- 分析了SCZ和心血管疾病风险因素的全基因组关联研究 (GWAS) 结果.
- 两变因果混合模型 (MiXeR) 估计了共享变体数量.
- 合并虚假发现率 (conjFDR) 确定了特定的共享位置.
主要成果:
- 在SCZ和吸烟开始 (8.6K变体) 和BMI (8.1K变体) 之间发现了广泛的遗传重叠.
- 特定的共享位置被确定为BMI,腰比,吸烟,血压,2型糖尿病,脂质和冠状动脉疾病.
- 功能分析揭示了涉及的基因在大脑和免疫细胞中表达.
结论:
- 研究结果表明,SCZ中存在吸烟的遗传倾向和降低肥胖风险.
- 共同位置的双向影响可能解释SCZ亚组中CVD风险和并发症的差异.
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