阻断性睡眠呼吸暂停综合征患者的系统性炎症状况以及肝素结合蛋白的预测值
Zongpei Yang1, Zhen Xue2, Yuejin Tao1
1Department of Otolaryngology, Head and Neck Surgery, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, The People's Republic of China.
肝素结合蛋白 (HBP) 在阻塞性睡眠呼吸暂停综合征 (OSAS) 患者中升高,并作为一个独立的风险因素. 乙型肝炎呈现出作为OSAS诊断生物标志物的潜力,表明改变了炎症状态.
科学领域:
- 睡眠医学 睡眠医学
- 免疫学 免疫学 免疫学
- 生物标志物 生物标志物
背景情况:
- 阻塞性睡眠呼吸暂停综合征 (OSAS) 与全身炎症有关.
- 肝素结合蛋白 (HBP) 是中性粒细胞激活和炎症的标志物.
研究的目的:
- 为了调查OSAS患者的全身炎症状况.
- 为了评估HBP对OSAS诊断的预测价值.
主要方法:
- 79名OSAS患者和28名通过多睡眠学 (PSG) 诊断的对照者的回顾性研究.
- 对外围血液中性粒细胞计数,淋巴细胞计数,中性粒细胞与淋巴细胞比率 (NLR),前素 (PCT) 和HBP水平进行比较.
- 使用接收机操作特征 (ROC) 曲线和后勤回归进行分析.
主要成果:
- 与对照组相比,OSAS患者的中性粒细胞,淋巴细胞和HBP水平显著更高 (P < .05).
- HBP显示OSAS预测曲线下的面积 (AUC) 为0.79 (灵敏度为80.49%,特异性为70.83%).
- 结合BMI,中性粒细胞,淋巴细胞和HBP,改善了OSAS预测 (AUC为0.89,灵敏度为80.49%,特异性为87.50%). 确定BMI和HBP是独立的风险因素.
结论:
- 高血压是OSAS的一个独立风险因素和潜在的诊断生物标志物.
- OSAS患者表现出改变的全身炎症状态.
- 升高的HBP可能表明OSAS患者对严重细菌感染的易感性增加.
更多相关视频
04:53Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
Published on: October 18, 2024
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
相关概念视频
Sleep Apnea
The condition is more prevalent among...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Pulmonary Embolism I: Introduction
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Drug Binding to Blood Components
HSA is the most abundant plasma protein and is vital in drug binding. It contains distinct drug-binding sites, with different drugs exhibiting affinity for specific sites. There are three main drug-binding domains for HSA: sites I, II, and III. These domains are...
