细胞环境对体外药物查的影响
Aiman Moldasheva1, Laura Bakyt1, Denis Bulanin1
1Department of Biomedical Science, Nazarbayev University School of Medicine, Astana, 010000, Kazakhstan.
Future science OA
|September 27, 2023
概括
细胞培养中的药物查通常由于实验室系统和整个生物体之间的差异而失败. 结合微环境和药物机械因素可以提高准确性,从而改善药物开发.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 细胞生物学 细胞生物学
- 生物医学工程 生物医学工程
背景情况:
- 药物开发面临高失败率,原因是毒性,不良影响和无效性.
- 现有的细胞培养模型不能完全复制复杂的体内环境,导致不准确的预测.
- 人类表型细胞提供相关性,但由于微环境影响,可以产生假阳性.
研究的目的:
- 突出目前细胞培养模型在预测药物疗效方面的局限性.
- 强调在药物查中需要考虑微环境和药物机械因素的必要性.
- 倡导更复杂的组织培养系统,以改善药物开发结果.
主要方法:
- 审查现有的关于药物开发失败和细胞培养方法的文献.
- 分析微环境刺激对细胞反应的影响.
- 在组织工程和药物测试的背景下讨论药物机械原理.
主要成果:
- 细胞在体外的反应被周围的微环境显著调节.
- 药物和机械力量在药物向相互作用和细胞行为中起着至关重要的作用.
- 由于这些未解决的因素,当前的选方法可能会高估或低估药物的疗效.
结论:
- 精确的药物查需要复杂的细胞和微环境因素相互作用的模型.
- 将微环境和药物机械方面的考虑纳入组织培养药物查中,对于减少晚期药物失效至关重要.
- 未来的药物开发应该利用更好地模仿体内条件的先进体外模型.
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