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不同的空间学习,增强的神经转录和血脑屏障障碍在从伤害后睡眠碎片化中恢复期间发展

Zoe M Tapp¹, Cindy Ren¹, Kelsey Palmer¹

¹Department of Neuroscience, College of Medicine, College of Dentistry, The Ohio State University, Columbus, Ohio, USA.

Neurotrauma reports

|September 27, 2023

概括

创伤性脑损伤 (TBI) 后的睡眠碎片化会导致持续的行为变化和血脑屏障功能障碍,即使在康复后也是如此. 这强调了需要管理TBI后的睡眠障碍,以获得更好的结果.

科学领域:

神经科学是一个神经科学.
创伤性脑损伤研究研究
炎症和免疫学炎症和免疫学

背景情况:

创伤性脑损伤 (TBI) 可以导致慢性神经炎症和降低生活质量.
睡眠碎片化 (SF) 是一种压力因素,可以在TBI后恶化神经炎症.
了解创伤后SF的长期影响对于改善患者护理至关重要.

研究的目的:

研究小鼠创伤性脑损伤 (TBI) 后睡眠碎片化 (SF) 的持久行为和炎症后果,即使经过恢复期.
为了确定SF是否会在TBI后加剧神经炎症和血脑屏障 (BBB) 功能障碍.

主要方法:

雄性和雌性小鼠接受了中度横向流体打击TBI或假手术.
一半的TBI和假装组每天暴露在SF中30天.
在行为和分子分析之前,小鼠从SF (SF-R) 恢复了30天 (受伤后30-60天).

主要成果:

虽然全球认知表现不受影响,但暴露于SF的TBI小鼠在康复后的测试几天内显示学习受损.
这些小鼠表现出神经元基因的表达增加和血脑屏障 (BBB) 功能障碍的迹象.
具体来说,改变的Aquaporin-4 (AQP4) 表达和增加的CD45+细胞表明持续的BBB破坏和炎症.

结论:

创伤后睡眠碎片化会导致持续的,不同的行为变化和神经炎症.
持续的血脑屏障破坏是TBI后的SF的一个关键后果.
在TBI后管理睡眠障碍对于减轻长期负面结果至关重要.

关键词:

巴恩斯迷宫是一个迷宫.血脑屏障血脑屏障血脑屏障血脑屏障侧流体打击力侧流体打击力睡眠的碎片化睡眠的碎片化

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