成年人与输血相关的移植对宿主疾病
Erwa Eltayib Elmakki1, Mohammed Ali Madkhali1, Omar Oraibi1
1Department of Internal Medicine, Faculty of Medicine, Jazan University, Jazan, SAU.
Cureus
|September 27, 2023
概括
输血相关的移植对宿主疾病 (TA-GVHD) 是一种致命的输血并发症. 通过血液辐射进行预防是关键的,因为这种罕见但致命的疾病的治疗方法在很大程度上无效.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 输血医学 输血医学
背景情况:
- 输血相关的移植对宿主疾病 (TA-GVHD) 是输血的罕见致命并发症.
- 它表现为发烧,皮疹,黄,腹和全细胞减小,往往导致>90%的死亡率.
研究的目的:
- 提高医疗从业人员对TA-GVHD的认识.
- 审查TA-GVHD的病理生理学,危险因素,诊断和管理.
主要方法:
- 手动从Medline,Scopus和谷歌学者中提取数据.
- 对选定的文章进行修订和评估,以便为TA-GVHD提供知识贡献.
主要成果:
- 由于免疫缺陷或HLA匹配,当供体T细胞攻击受体组织时,TA-GVHD发生.
- 风险因素包括宿主免疫缺陷,新鲜血液输血和部分HLA匹配 (例如,亲属捐赠者,血缘关系人口).
- 诊断是临床的,通过活检确认;治疗通常是无效的,干细胞移植是罕见的选择.
结论:
- 通过血液辐射进行预防是标准的护理.
- 医疗从业人员需要对TA-GVHD的高度怀疑指数.
- 需要进一步的临床试验来比较TA-GVHD治疗选择.
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