与登诺苏马布相关的围假体非典型大腿骨折:一个病例报告
Satomi Abe1, Masahiro Inoue1, Takashi Mikami1
1Department of Orthopedic Surgery, Eniwa Hospital, 2-1-1 Koganechuou Eniwa 061-1449, Japan.
Journal of orthopaedic case reports
|September 27, 2023
概括
本病例报告详细介绍了一名因骨质疏松症而接受德诺苏马布治疗的患者罕见的非典型周围假肢股骨骨折. 长期使用德诺苏马布可能会增加这种骨折的风险.
科学领域:
- 整形外科 整形外科 整形外科
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 德诺苏马布是绝经后骨质疏松症的常见治疗方法,通常使用5-10年.
- 虽然已知双酸盐会导致异常骨折,但与登诺苏马布相关的病例很少被报告.
- 周围假肢骨骨折是患有骨质疏松症的患者的潜在并发症.
研究的目的:
- 报告一个罕见的异常周围假肢股骨折与denosumab使用相关的病例.
- 突出denosumab在引起非典型的股骨骨折方面的潜在风险,特别是在长期使用者中.
- 为了有助于理解与denosumab相关的骨不良事件.
主要方法:
- 一位75岁的绝经后骨质疏松症妇女的案例研究,接受了denosumab治疗.
- 详细描述非典型的周围假肢大腿骨折,包括成像发现.
- 手术干预和术后愈合的文件.
主要成果:
- 患者在开始denosumab治疗后31个月经历了非典型的周围假肢股骨骨折.
- 骨折是横向的,到大腿茎的尖端与侧面皮层加厚.
- 使用更长的固干进行修复手术,在10个月内成功治愈骨折.
结论:
- 这是第一次报告与denosumab相关的周围假肢非典型股骨骨折的病例.
- 长期的德诺苏马布治疗可能是患上周围假肢非典型股骨骨折的危险因素.
- 需要进一步的研究来阐明与登苏马布相关的非典型骨折的机制和发病率.
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