儿童注意力缺陷/多动障碍 (ADHD) 和ADHD症状维度的联合多基因和环境风险
Michael A Mooney1,2, Peter Ryabinin2, Hannah Morton3
1Division of Bioinformatics and Computational Biology Department of Medical Informatics and Clinical Epidemiology Oregon Health & Science University Portland Oregon USA.
JCPP advances
|September 27, 2023
概括
遗传和环境因素,包括家庭冲突,显著预测注意力缺陷/多动症 (ADHD) 症状. 结合这些风险可以改善预测模型,但祖先差异需要进一步调查,以确保公平的护理.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
- 环境健康 环境健康
背景情况:
- 注意缺陷/多动障碍 (ADHD) 源于遗传倾向和环境影响.
- 了解ADHD遗传和环境风险之间的相互作用对于开发预测模型至关重要.
研究的目的:
- 研究多基因风险评分 (PRS) 和环境因素对ADHD症状的附加和相互作用影响.
- 评估将遗传和环境数据用于ADHD预测的实用性.
主要方法:
- 使用了两个独立的数据集 (ABCD和俄勒冈-ADHD-1000) 与横截面设计.
- 检查了九种心理健康状况的PRS,以及家庭收入,冲突,地区剥夺,暴露和空气污染等环境因素.
- 分析的添加剂 (G+E) 和相互作用 (GxE) 效应.
主要成果:
- ADHD PRS和家庭冲突共同预测了两个队列中的ADHD症状.
- 结合遗传和环境因素的添加模型解释了明显更多的症状变异,而不是单个因素.
- 对于某些遗传和环境因素,在祖先群体之间观察到效应大小的显著异质性.
结论:
- PRS和家庭环境对ADHD症状的附加效应是可重现的.
- 基因-环境 (GxE) 相互作用效应没有得到一致的复制,并且可能会被祖先混.
- 结合环境暴露和PRS显示出临床预测算法的前景,并呼吁进一步研究祖先特异性风险,以防止医疗保健差异.
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