青少年失眠的亚型:从定量/分子双胞胎研究的见解
Juan J Madrid-Valero1, Frühling Rijsdijk2, Saskia Selzam2
1Department of Health Psychology Faculty of Health Sciences University of Alicante Alicante Spain.
JCPP advances
|September 27, 2023
概括
在青少年中,睡眠时间短的失眠与焦虑和抑郁有更强烈的联系. 对失眠的遗传和环境影响在短睡眠组和正常/长睡眠组之间没有显著差异.
科学领域:
- 睡眠科学 睡眠科学
- 遗传学 是一个遗传学.
- 青少年健康 青少年健康
背景情况:
- 失眠的亚型,特别是睡眠时间较短的亚型,理论上是更严重和受遗传影响的.
- 以前的研究还没有直接比较失眠亚型的遗传性和遗传基础.
- 这项研究调查了青少年失眠亚型的遗传和环境因素.
研究的目的:
- 在青少年中,比较短睡眠时间和正常/长睡眠时间亚型之间的失眠症状遗传性.
- 在这些亚型中检查失眠和睡眠持续时间的多基因分数 (PGS).
- 评估失眠亚型与各种特征/疾病之间的关联.
主要方法:
- 利用了来自双胞胎早期发育研究中的4000对16岁双胞胎的数据.
- 应用双胞胎模型来估计不眠症症状的遗传性,用于两个睡眠持续时间亚型.
- 计算并比较了两组之间的失眠和睡眠时间的多基因分数.
主要成果:
- 在短睡眠 (A=0.13) 和正常/长睡眠 (A=0.35) 两组之间,失眠的遗传概率估计没有显著差异.
- 共享的环境因素对短睡眠持续时间失眠 (C=0.19) 的变异有显著的贡献,但不是正常/长睡眠持续时间失眠 (C=0.00).
- 多基因分数在各组之间没有显著差异. 睡眠时间较短的失眠与焦虑和抑郁症有较强的关联 (p < .05).
结论:
- 关于青少年失眠亚型之间的预期差异,研究结果呈现出不同的结果.
- 需要进一步的研究来定义不同发育阶段的"短"睡眠时间,并利用客观的睡眠指标.
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