区域性身体组成变化对在袖子胃切除术后骨密度重塑的影响
Di Yang1, Rongrong Xu1, Yinfang Tu1
1Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Frontiers in endocrinology
|September 27, 2023
概括
袖子胃切除术 (SG) 会导致骨矿物质密度 (BMD) 丧失,特别是在部和大腿部. 身体组成的变化,而不仅仅是总体体重减轻,显著影响了手术后的BMD减轻.
科学领域:
- 腹部外科 腹部外科
- 骨的新陈代谢 骨的新陈代谢
- 肥胖管理 肥胖管理
背景情况:
- 袖子胃切除术 (SG) 与骨矿物质密度 (BMD) 损失和身体成分改变有关.
- 身体成分变化对后SG骨健康的具体影响仍然不清楚和争论.
研究的目的:
- 在袖子胃切除术12个月后,调查身体组成变化和骨质量损失之间的关系.
- 为了提供有关驱动BMD减少的机制的见解,在SG之后.
主要方法:
- 对41名肥胖的中国人 (25名女性,16名男性) 进行前性研究,接受了SG.
- 收集的数据包括人类测量,身体组成,骨质量和血液样本,至少持续12个月.
主要成果:
- 在12个月后,两种性别都观察到大腿部 (FN) 和部 (TH) BMD 的显著下降,与腰椎 (LS) BMD 不一样.
- 在6个月内,FN BMD损失与女性估计的无脂肪质量指数 (eFFMI) 减少和男性估计的皮下脂肪面积 (SFA) 减少相关.
- 在12个月内,内脏脂肪面积 (VFA) 的减少与两性男性的FN BMD损失有负相关性,而腰围的减少与女性的TH BMD损失相关.
结论:
- 袖子胃切除术在男性和女性中都会导致大腿部和整个部的BMD显著减少.
- 身体组成的变化,而不是单独的总体体重减轻,是影响BMD变化的关键因素,这些变化发生在SG后的各种地点和时间点.
- 界定身体成分变化对于理解和管理袖子胃切除术后的BMD损失至关重要.
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