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在住院COVID-19患者的入院时,Interleukin-6和NT-proBNP之间的非线性关系

Meijuan Zhang¹, Zhanquan Jiao¹

¹Department of Cardiology, Tianjin Institute of Respiratory Diseases, Tianjin Haihe Hospital, Tianjin University, Tianjin, People's Republic of China.

Infection and drug resistance

|September 27, 2023

概括

这项研究在COVID-19患者中发现了介质素-6 (IL-6) 和N-终端亲B型尿素 (NT-proBNP) 之间的非线性关系. 较高的IL-6水平与增加的NT-proBNP相关,这表明这些人的心脏应变.

科学领域:

心脏病学心脏病学
传染性疾病传染性疾病
生物标志物研究生物标志物研究

背景情况:

在COVID-19患者中观察到高水平的互白素-6 (IL-6) 和N-终端亲B型性尿素 (NT-proBNP).
在COVID-19中IL-6和NT-proBNP之间的特定关系需要进一步调查.

研究的目的:

在被诊断为COVID-19的患者中研究IL-6和NT-proBNP水平之间的关系.

主要方法:

采用了横截面研究设计.
分析了121名连续的COVID-19患者.
进行了包括曲线拟合在内的单变量和多变量回归分析,以评估IL-6和NT-proBNP之间的关联.

主要成果:

在IL-6和NT-proBNP水平之间发现了非线性关联.
在完全调整的模型中,较高的IL-6水平与NT-proBNP显著相关,特别是超过2.7的拐点 (β = 0.77,P = 0.016).
单变量分析显示出显著的正相关性 (β = 0.28,P = 0.001),尽管在完全调整的模型中 (β = 0.09,P = 0.176) 这一比例有所下降.

结论:

这项研究表明,在COVID-19患者中,IL-6和NT-proBNP之间存在非线性关系.
升高的IL-6水平与增加的NT-proBNP有关,这表明潜在的心脏参与COVID-19的进展.

关键词:

在 COVID-19 疫情中,NT-proBNP 的国家统计数据.互乐金-6是其中的一种.非线性关联是一种非线性关联.

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