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在慢性呼吸道疾病的老年人中,口服皮质类固醇的使用和与copenia相关的特征:基于人口的研究
Elizabeth Benz1,2, Lies Lahousse1,3, Johnmary T Arinze4,5
1Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
口服皮质类固醇 (OCS) 的使用与COPD患者的手握强度降低有关. 这种下降取决于OCS的频率和持续时间,这表明需要对这些人进行定期的肌肉评估.
科学领域:
- 老年学是指老年学的学科.
- 药理学 药理学是指药理学的学科.
- 肺部病理学 肺部病理学
背景情况:
- 标志着手握强度低 (HGS) 和尾骨肌指数 (ASMI) 的麻症是老年人群的重大健康问题.
- 口服皮质类固醇 (OCS) 对于治疗COPD和喘恶化至关重要,但它们对老年人肉症的影响仍未得到充分研究.
- 这项研究探讨了OCS使用和肉症组件之间的关系,特别是在患有慢性呼吸道疾病的个体中.
研究的目的:
- 为了检查口服皮质类固醇 (OCS) 使用与手握强度 (HGS) 或尾骨肌指数 (ASMI) 在一般老年人群中之间的关联.
- 探索OCS使用与慢性呼吸道疾病 (如COPD和喘) 之间有关肌肉健康的潜在相互作用.
- 为了确定OCS使用是否影响肌肉力量和质量纵向.
主要方法:
- 利用了基于人口的鹿特丹研究的数据,包括5054名参与者进行横截面分析和1324名参与者进行纵向分析.
- 采用线性回归模型来分析OCS使用与肌肉强度/质量之间的关联,调整为关键共变量,如年龄,性别和并发症.
- 评估手握强度和肌肉质量与OCS处方频率和持续时间的关系.
主要成果:
- 与从未使用OCS的用户相比,从来使用OCS的用户在基线上表现出较低的手握强度,对累积的OCS频率观察到剂量依赖的效果.
- 使用OCS的COPD患者的手握强度和肌肉质量明显低于使用OCS的非OCS患者.
- 纵向分析显示,曾经使用过OCS的COPD患者随着时间的推移,手握强度下降,相关性取决于OCS的频率和持续时间.
结论:
- 口服皮质类固醇 (OCS) 的使用与COPD患者手握强度的下降有关,这种方式取决于累积的OCS频率和持续时间.
- 这些发现凸显了OCS在COPD患者中的潜在肌肉毒性作用.
- 常规的肌肉质量和力量检查建议COPD患者,特别是那些接受OCS治疗的患者.
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