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Updated: Jul 15, 2025

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord
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细胞矩阵神经移植的基础机制修复外围神经缺陷

Shanshan Wang1,2, Hongkui Wang1, Panjian Lu1

  • 1Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, Jiangsu, 226001, PR China.

Bioactive materials
|September 27, 2023
PubMed
概括

这项研究使用人类骨髓中介细胞干细胞衍生的脱细胞化细胞外基质 (hBMSC-dECM) 开发了一种新的神经移植. hBMSC-dECM移植的功能恢复与自体移植相似,促进神经再生和血管化.

关键词:
脱细胞化 脱细胞化细胞外矩阵是细胞外矩阵.周围神经的再生和再生组织工程是组织工程.hBMSCC 这是一个很好的方法.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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