用于智能药物输送的可逆交叉连接的两性聚合物菌片的制备,具有pH响应性行为
Liu Tan1,2, Jinling Fan1, Yuqing Zhou1
1School of Chemical Engineering, Xiangtan University Xiangtan 411105 China huding@hnu.edu.cn xdwuzm@xtu.edu.cn.
RSC advances
|September 27, 2023
概括
研究人员开发了新的pH响应的聚合物微粒,用于黄素的输送. 这些菌体表现出极好的稳定性和受控的药物释放,模拟证实了它们的自我组装和行为.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 纳米技术纳米技术
背景情况:
- 开发稳定和响应的药物输送系统对于向治疗至关重要.
- 聚合物微粒为封装水药物 (如黄素) 提供了潜在的潜力.
- 响应pH的材料可以在特定的生物环境中实现可控的药物释放.
研究的目的:
- 为了合成和表征一种新型的可逆交叉链接,对pH反应的聚合物微粒 (PM),用于黄素的输送.
- 评估合成的PMs的稳定性,药物负载,捕获效率和释放特征.
- 通过消散粒子动力学 (DPD) 模拟来研究自我组装和pH响应性行为.
主要方法:
- 聚[聚乙烯糖醇甲烯酸-co-2-(acetoacetoxy) 乙烯甲烯酸]-b-聚 [2-(dimethylamino) 乙烯甲烯酸] 阻断共聚物的合成.
- 聚合物微粒的形成和特征.
- 评估关键菌度 (CMC),负载能力和捕获效率.
- 在不同pH值 (7.4和5.0) 的体外药物释放研究.
- 分散粒子动力学 (DPD) 模拟用于自我组装和行为分析.
主要成果:
- 合成的PMs表现出具有可逆交叉链接和pH响应的核心外结构.
- P(PEGMA9-co-AEMA6)-b-PDMAEMA10显示了较低的CMC (0.0041 mg mL-1),高负载能力 (13.86%),以及高的捕获效率 (97.03%).
- 在pH 7.4 (12.36%在108小时内) 观察到黄素的持续释放,而在pH 5.0 (42.36%) 发生快速释放.
- DPD模拟验证了关于自我组装和pH响应行为的实验发现,确定了最佳的药物载体比率和水分.
结论:
- 一个新的可逆交联,pH响应的聚合物微粒系统已成功开发用于黄素的输送.
- 该系统表现出卓越的结构稳定性和基于pH的调节性药物释放特性.
- DPD模拟是研究这些先进药物递送系统的特性和优化设计的宝贵工具.
- 这项研究为开发具有增强稳定性和受控释放的自分解药物输送系统 (SDDS) 提供了一个有前途的平台.
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