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Helen Elizabeth Ritchie¹, Jaimie W Polson¹, Andrea Xia¹

¹School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, NSW, Australia.

Current research in toxicology

|September 27, 2023

概括

芬波西丁可能会通过影响心率而对胎儿造成伤害,但对人类来说,有效剂量不太可能. 如果温波因与成人心律失常有关,则需要进一步研究.

科学领域:

药理学药理学是指药理学的学科.
发育毒理学发展毒理学
心血管科学心血管科学

背景情况:

维诺,一种用于记忆和减肥的补充剂,抑制了Ikr电流,对心脏再极化至关重要.
抑制Ikr可以导致危险的节律失常,如torsade de pointes和突然死亡.
在动物研究中,IKR抑制剂已经显示出产性作用,包括出生缺陷和胚胎死亡率.

研究的目的:

为了研究温波西丁及其代谢物阿波文卡明酸对胚胎心率的影响.
为了澄清文波西丁潜在的胎儿毒性背后的机制.

主要方法:

用老鼠胚胎培养来评估温波西丁和阿波文卡明酸的影响.
对胚胎心率进行了监测,以应对不同度的化合物.

主要成果:

芬波西丁和阿波文卡明酸都诱导了度依赖的胚胎心.
芬波西丁在引起心肌梗塞方面更强大,在100nM时观察到效应.
胚胎心律失常发生在较高度,而文波是更强大的.

结论:

这项研究表明,FDA对文波西丁的警告可能会导致不必要的焦虑,因为有效度在人类中不太可能.
如果确立了文波西丁与成人心律失常之间的联系,则需要重新评估致性风险.

关键词:

出生缺陷是一种出生缺陷.心脏的功能心脏的功能在体外查维波西丁 (Vinpocetine) 是一种葡萄素.希尔格 (HERG) 是一个

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