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雌性大鼠15天禁食后寻求氧的雌性周期和轨道前皮层在氧中的作用
Adedayo Olaniran1, Rachel D Altshuler1, Megan A M Burke1
1Department of Psychology, University of Maryland College Park, College Park, Maryland, USA.
Addiction biology
|September 27, 2023
概括
雌性周期不会影响雌性大鼠的氧化摄入量或渴望化. 轨道前皮层 (OFC) 仍然对化氧化在女性寻求的过程至关重要,类似于男性.
科学领域:
- 神经科学是一个神经科学.
- 成研究 研究成研究
- 行为药理学行为药理学
背景情况:
- 在老鼠中观察到氧化渴望的潜伏,禁欲后寻求药物的逐渐增加.
- 在雄性大鼠中,轨道前皮层 (OFC) 对这种现象至关重要.
- OFC的作用和雌性大鼠雌性月经周期的影响仍然未被探索.
研究的目的:
- 为了研究雌性大鼠化周期对化氧化寻找的效果.
- 为了确定OFC在化氧化寻找中的作用是否延伸到雌性大鼠.
- 在此背景下,评估化学遗传学在研究OFC功能的有效性.
主要方法:
- 在雌性大鼠中,在雌性老鼠的雌性周期的不同阶段评估了氧化自给和渴望的潜伏.
- 使用JHU37160 (J60) 与专用药物 (DREADDs) 独家激活的设计受体进行OFC的化学遗传失活.
- 对照组接受了单独的J60或没有DREADD治疗.
主要成果:
- 在自我管理培训期间,氧化的摄入量在雌性期,雌性期前期和雌性期中没有差异.
- 在非雌性和雌性雌性老鼠之间,化氧化寻求水平与非雌性雌性老鼠相似.
- 化学遗传性OFC无活化显著降低了化氧化寻求,而J60在对照大鼠中没有影响.
结论:
- 在研究的条件下,雌性大鼠的雌性周期不会影响氧化摄入量或氧化渴望的潜伏期.
- 轨道前皮层 (OFC) 对于在雌性大鼠中化氧化寻找至关重要,反映了雄性大鼠的发现.
- 这些结果突出了OFC在不同性别的成相关行为中的保留作用.
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