内源性阿片类系统以性别依赖的方式调节条件可卡因奖励
Kanako Matsumura1,2, Amélia Nicot3, In Bae Choi4
1Institute for Neuroscience, The University of Texas at Austin, Austin, Texas, USA.
Addiction biology
|September 27, 2023
概括
在寻找可卡因的行为中,状脑不是必不可少的. 然而,阿片类药物对抗剂阻断了雌性小鼠的可卡因偏好表达和灭绝,这表明性别特定的阿片类药物参与了可卡因使用障碍.
科学领域:
- 神经科学是一个神经科学.
- 行为药理学行为药理学
- 成研究 研究成研究
背景情况:
- 寻找可卡因受到预测线索和背景的影响.
- 由阿片类调节的状回路编码有条件的行为.
- 之前的研究将条状脑素与可卡因条件的位置偏好 (CPP) 获得和阿片类抗体与CPP表达联系起来.
研究的目的:
- 调查状脑是否对于可卡因CPP的获取和灭绝是必要的.
- 检查条状脑在可卡因诱导行为的表达和灭绝中的作用.
- 探索阿片类受体对抗剂对可卡因CPP的影响的性别差异.
主要方法:
- 产生的小鼠有针对性地从多巴胺D2受体中删除恩基法林,表达中等棘手神经元.
- 利用可卡因条件的位置偏好 (CPP) 范式来评估行为反应.
- 使用纳洛 (阿片类受体对抗剂) 来评估其对CPP表达和灭绝的影响.
主要成果:
- 较低的条状脑素水平并没有影响可卡因CPP的获取.
- 纳洛在雌性小鼠中阻止了可卡因CPP的表达,不论其基因型如何.
- 无论基因型如何,雌性都比雄性更快地消灭偏好,这种效应在灭绝训练期间被纳洛阻止.
- 这些发现表明,条状脑不是可卡因CPP获得,表达或灭绝的关键.
结论:
- 对于可卡因的获得,表达或灭绝,状脑是不必要的.
- 雌性中可卡因偏好表达和灭绝是由除条性脑神经外的其他阿片类介导的.
- 对阿片类药物抗剂的反应中的性别差异凸显了在可卡因使用障碍治疗策略中考虑性别的重要性.
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