斯皮尔曼式相关度衡量,对双变异生存数据中的共变量进行调整
Svetlana K Eden1, Chun Li2, Bryan E Shepherd1
1Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Biometrical journal. Biometrische Zeitschrift
|September 27, 2023
概括
我们引入了一种新方法来估计对审查数据的斯皮尔曼相关性,允许对共变量进行调整. 这种方法只使用边际生存分布,为现有方法提供较少变量的替代方案.
科学领域:
- 生物统计学 生物统计学
- 生存分析的分析.
- 统计相关性 统计相关性
背景情况:
- 对于被审查的数据,现有的斯皮尔曼相关性估计器具有局限性.
- 非参数方法需要复杂的双变异生存表面估计.
- 半参数方法依赖于对依赖结构的潜在非参数假设.
研究的目的:
- 建议对被审查的连续和离散数据的斯皮尔曼相关性进行新的扩展.
- 为了使相关性估计中的共变量调整.
- 提供一种方法,避免复杂的生存表面估计和限制性参数假设.
主要方法:
- 拟议的方法估计了概率尺度残余的相关性.
- 它仅依赖于边际生存分布,而不是双变表面或参数模型.
- 该方法扩展到计算部分,条件和部分条件相关性.
主要成果:
- 新方法的变化比现有的非参数估计器要小.
- 信心区间很容易构建.
- 虽然在审查下有偏见,但它表现良好,平均平方误差小于在中度审查下非参数方法的平均平方误差.
结论:
- 拟议的方法提供了一种实用且强大的扩展Spearman对审查数据的相关性与共变量调整.
- 这对于已知或可靠估计边际分布的应用特别重要.
- 该方法已成功应用于估计艾滋病毒感染者队列中的相关性.
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