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Updated: Jul 15, 2025

A Standard Methodology to Examine On-site Mutagenicity As a Function of Point Mutation Repair Catalyzed by CRISPR/Cas9 and SsODN in Human Cells
10:07

A Standard Methodology to Examine On-site Mutagenicity As a Function of Point Mutation Repair Catalyzed by CRISPR/Cas9 and SsODN in Human Cells

Published on: August 25, 2017

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大多数DNA修复缺陷不会改变CRISPR编辑细胞中相对生物有效性和线性能量转移之间的关系

Francisco D C Guerra Liberal1, Jason L Parsons2, Stephen J McMahon1

  • 1The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.

Medical physics
|September 27, 2023
PubMed
概括

DNA双链断裂 (DSB) 修复缺陷,特别是在非同源端结合 (NHEJ) 中,无论辐射类型如何,都显著增加了癌细胞的放射敏感性. 这凸显了DNA修复途径在确定辐射反应中的重要性.

关键词:
克里斯普尔-Cas9是什么意思造成的DNA损伤是DNA损伤.修复DNA的修复DNA的修复在RBE中,RBE就是RBE.高 LET 高 LET 的时间.同类的重组组合.不同类型的末端连接质子疗法是一种质子疗法.辐射辐射辐射辐射的辐射辐射敏感性 辐射敏感性

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Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter06:59

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