血清学调查的持续的状缩在乳病的疾病
Changlin Gong1, Claudia Saborit1, Xin Long1
1Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
在不含谷蛋白饮食的乳病患者中,持续性小性缩不被组织转谷氨酶 (tTG) 抗体预测得很好. 低的LDL胆固醇和高的炎症性细胞因子与持续的小性缩有关.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 尽管坚持无质饮食 (GFD),但在腹腔疾病 (CeD) 患者中可能会发生持续性小性缩 (VA).
- 在随访期间确定VA的可靠生物标志物对于管理CeD至关重要.
- 当前的生物标志物可能无法准确地反映GFD患者的VA存在.
研究的目的:
- 评估血清生物学生物标志物,以预测持续性小性缩 (VA) 在无性疾病 (CeD) 患者的无质饮食 (GFD).
- 调查VA与特定的自身抗体,细胞因子和阿波利波蛋白之间的潜在关联.
主要方法:
- 对122个来自对照组和CeD患者的血清样本进行了回顾性分析 (初始诊断和随访).
- 开发一种内部多重检测法,以测量自身抗体 (包括tTG-IgA/IgG),细胞因子和阿波利波蛋白.
- 样本分类为非乳控制,非VA CeD (Marsh 0-2) 和VA CeD (Marsh 3a-3c) 组.
主要成果:
- 组织转谷氨酶 (tTG) -IgA抗体对于初始CeD诊断是有效的,但对于随访期间预测VA是不理想的,其中14.6%的VA患者显示低tTG-IgA.
- 增加tTG-IgA的稀释改善了量化,但没有改善VA检测.
- 在一些患者中,持久的VA与显著降低低密度脂蛋白胆固醇水平 (P=0.03) 和增加的促炎细胞因子相关.
- 在GFD附属和非附属患者之间,阿波利波蛋白水平有差异,但在VA和非VA组之间没有差异.
结论:
- 组织转谷氨酶 (tTG) -IgA是一种不可靠的生物标志物,用于预测无质缩 (VA) 在坚持无质饮食 (GFD) 的乳病 (CeD) 患者中.
- 持续的VA与低密度脂蛋白胆固醇的降低和潜在的炎症性细胞因子的升高有关.
- 需要进一步的研究来确定准确的生物标志物持续的VA在GFD的CeD患者.
更多相关视频
07:39Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models
Published on: September 1, 2023
06:26Use of Anti-phospho-girdin Antibodies to Visualize Intestinal Tuft Cells in Free-Floating Mouse Jejunum Cryosections
Published on: March 21, 2018
相关概念视频
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Histology of the Small Intestine
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Serum Laboratory Studies, Stool Test, Breath Test
