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TRAV26-2 T-细胞受体表达与功能性消化不良患者的粘膜淋巴细胞对小麦蛋白的反应有关

Grace L Burns^1,2,3, Michael Potter^2,3,4,5, Andrea Mathe^1,3

¹School of Biomedical Sciences & Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, Australia.

Clinical and translational gastroenterology

|September 27, 2023

概括

小麦抗原,特别是质素,在功能性消化不良 (FD) 患者的十二指肠中引起免疫反应. 这表明,淋巴细胞对小麦蛋白质的反应改变有助于FD.

科学领域:

胃肠病学胃肠病学
免疫学免疫学免疫学
饮食科学饮食科学

背景情况:

观察性研究表明,功能性消化不良 (FD) 和小麦消费之间存在联系.
以前的研究还没有证明FD中对小麦抗原的适应性免疫反应.

研究的目的:

调查小麦抗原是否可以触发FD患者十二指腺淋巴细胞的反应.
探索特定的小麦蛋白质,如质素在FD病变发生中的作用.

主要方法:

从FD患者和对照组的十二指肠活检中分离自身膜单核细胞 (LPMCs).
用素和质刺激LPMCs,然后进行流细胞计和定量PCR.
对T细胞受体α变体 (TRAV) 26-2基因表达的分析.

主要成果:

与对照人群相比,格里亚丁刺激增加了FD LPMCs中Th2类淋巴细胞的效能.
在FD患者中,TRAV26-2的十二指腺基因表达下降.
在FD患者暴露于质后,在TRAV26-2表达和效应体Th17样细胞之间发现了积极的关联.

结论:

在FD患者中,素暴露会诱导十二指肠效应者Th2样反应.
这些发现支持食品抗原在某些FD病例中推动免疫反应的作用.
淋巴细胞对小麦蛋白质的改变反应与FD的发病有关.

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