维生素D水平下降是否会引发双极躁狂发作?
Okan İmre1, Mustafa Karaağaç2, Cuneyt Caglayan3
1Department of Psychiatry, Faculty of Medicine, Karamanoglu Mehmetbey University, Karaman 70200, Turkey.
Behavioral sciences (Basel, Switzerland)
|September 27, 2023
概括
与健康人相比,躁狂发作中双相情感障碍患者的维生素D (Vit D) 水平较低. 维生素D水平在缓解期间正常化,这表明在躁狂症中可能发挥作用.
科学领域:
- 精神病学是一个精神病学.
- 内分泌学 在内分泌学.
- 营养神经科学 营养神经科学
背景情况:
- 双极性障碍是一种导致严重残疾的慢性疾病,在一些患者中治疗反应不佳.
- 维生素D (Vit D) 与情绪障碍之间的联系正在引起人们的注意,特别是与抑郁症的关联.
- 双相情感障碍中维生素D和躁狂发作之间的关系仍然不太清楚.
研究的目的:
- 为了研究患有双相情感障碍急性躁狂发作的患者的血清维生素D (Vit D) 和代谢物水平.
- 为了比较双相情感障碍患者在躁狂发作和euthymic时期的维生素D水平与健康对照.
- 探索维生素D在双相躁狂病理生理学的潜在作用.
主要方法:
- 一项涉及34名双相躁狂发作患者和34名健康对照者的病例对照研究.
- 使用汉密尔顿抑郁症评分表 (HAM-D) 和青年躁狂评分表 (YMRS) 评估疾病活动.
- 在躁狂和死亡阶段测量血清25-氧维生素D (25-OHD), (Ca) 和 (P) 水平.
主要成果:
- 血清25-基维生素D (25-OHD) 水平在急性躁狂发作期间在双相患者显著较低,与健康对照组相比.
- 在躁狂患者和对照人群之间, (Ca) 和 (P) 水平没有显著差异.
- 血清25-OHD,Ca和P水平在缓解期 (euthymic期) 的双极患者和健康对照人群之间没有差异.
结论:
- 双相情感障碍中的急性躁狂发作与血清维生素D (Vit D) 度较低有关.
- 这些发现表明,维生素D缺乏可能导致躁狂发作,或是由于营养不良或躁狂期间减少阳光照射等因素造成的.
- 需要进一步的研究来澄清混因素,并检查双相情绪障碍的所有情绪状态中的维生素D.
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